Machine learning, automated microscopy, and evolutionary modeling for understanding and treating bacteria.
Ph.D. Computational Biology · GPA 3.8 (expected 2029) · Pittsburgh, PA
B.S. Molecular & Biomedical Biology · GPA 3.9 · Minors: Chemistry & Mathematics · Omaha, NE
GPA 4.8 · AP Scholar · Omaha, NE
Carja and Bridges Labs @ Carnegie Mellon University
Bio Design Kitchen @ Google X, The Moonshot Factory
Cooper Lab @ Univ. of Pittsburgh
UNeTECH @ Univ. of Nebraska Medical Center
Rowen Lab @ Univ. of Nebraska Omaha
Soukup Lab @ Creighton University
Mellick, S., Derringer, J., Boyes, D., Croteau, G., Burke, M., Gifford, S., Stark, D., Mike, L., Turecki, S., Carja, O., Mikheyeva-Bridges, I., Bridges, D. Genome-scale label-free imaging reveals cellular physiology encoded in bacterial collective architecture. bioRxiv (preprint).
Mellick, S., Rowen, D. Characterizing the role of PA5189 in Pseudomonas aeruginosa deletion and overexpression mutants. Undergraduate Honors Thesis, University of Nebraska Omaha.
Mellick, S., Rowen, D. Role of the PA5189 regulon in Pseudomonas aeruginosa antibiotic resistance and biofilm formation. Conference talk, Nebraska Academy of Sciences, Lincoln, NE.
10-710 Computational Genomics, CMU
Curated a dataset integrating genomic, evolutionary, kinetic, and structural features of synonymous mutations in S. cerevisiae and built interpretable models predicting fitness effects of synonymous mutations.
MSCBIO 2030 Computational Structural Biology, Pitt
Demonstrated that SO(3)-equivariant Boltzmann generators are necessary to capture chirality in molecular structures and latent representations, with implications for using traditional E(3)-equivariant models for modeling biomolecular systems and drug design.
10-701 Machine Learning, CMU
Studied transferability of localized adversarial perturbations across CNN and Vision Transformer architectures using FGSM, PGD, and Carlini-Wagner adversarial techniques combined with segmentation and bounding-box detection to localize perturbations to specific image regions.